The recent introduction of new vaccines into the school-based immunization program in British Columbia (BC) included monitoring of adverse events following immunization (AEFI) for these new vaccines. This commentary discusses different methods used to collect AEFIs in school immunization campaigns and the effects on response rate. The results of a study using an internet-based tool inspired this paper. The study examined adverse events following human papillomavirus (HPV) vaccine given to grades 6 and 9 students. The low response rate of the internet survey resulted in insufficient findings regarding adverse events. Consequent to the analysis of the study’s data, a literature review was conducted to examine survey methodologies used to collect adverse event data following school-based immunization of adolescents. A PubMed search used various combinations of the following terms: vaccine, immunization, immunization programs, reactogenicity, adverse reactions, safety, adolescent, schoolchildren, and survey. Potentially relevant papers were identified based upon the titles and abstracts and subsequently reviewed. Only four studies were deemed appropriate for comparison purposes: all were done in Canada.