This chapter addresses the main considerations in online survey research with sensitive topics. Advances in technology have allowed numerous options in addressing survey design, and thus created a need to evaluate and consider best approaches when using online survey research. This chapter identifies subjects such as item non-response in online survey research. In addition, this chapter includes a description of the differences in researching non-sensitive topics versus sensitive topics, and then lists a number of best practice strategies to reduce item non-response and improve the quality of survey data obtained. Included are specific considerations for defining sensitive topics and addressing gender differences when surveying more sensitive material. Additional resources in online survey research design are recommended.