The size of the cell-phone-only population in the USA has increased rapidly in recent years and, correspondingly, researchers have begun to experiment with sampling and interviewing of cell-phone subscribers. We discuss statistical issues involved in the sampling design and estimation phases of cell-phone studies. This work is presented primarily in the context of a nonoverlapping dual-frame survey in which one frame and sample are employed for the landline population and a second frame and sample are employed for the cell-phone-only population. Additional considerations necessary for overlapping dual-frame surveys (where the cell-phone frame and sample include some of the landline population) are also discussed. We illustrate the methods using the design of the National Immunization Survey (NIS), which monitors the vaccination rates of children age 19-35 months and teens age 13-17 years. The NIS is a nationwide telephone survey, followed by a provider record check, conducted by the Centers for Disease Control and Prevention.